The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2003
Filed:
Jul. 02, 2001
Applicant:
Inventors:
Andrew S. Little, Los Altos, CA (US);
Daniel R. Henderson, Palo Alto, CA (US);
Eric R. Schuur, Palo Alto, CA (US);
Henry Lamparski, San Mateo, CA (US);
Assignee:
Cell Genesys, Inc., Foster City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/800 ; C12N 1/5861 ; C12N 5/10 ; C12N 1/563 ; C12N 1/564 ;
U.S. Cl.
CPC ...
A61K 4/800 ; C12N 1/5861 ; C12N 5/10 ; C12N 1/563 ; C12N 1/564 ;
Abstract
Adenovirus vectors replication specific for cells expressing &agr;-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.