The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2003
Filed:
Nov. 28, 2000
Applicant:
Inventor:
Emad S. Alnemri, Ambler, PA (US);
Assignee:
Thomas Jefferson University, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01H 3/00 ; A61K 3/817 ; C07H 2/104 ; C07K 1/4435 ; C12N 5/10 ;
U.S. Cl.
CPC ...
A01H 3/00 ; A61K 3/817 ; C07H 2/104 ; C07K 1/4435 ; C12N 5/10 ;
Abstract
Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.