The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2003
Filed:
Jan. 28, 2002
Applicant:
Inventors:
Jordi Bosch i Lladó, Girona, ES;
Eugenia Pagans Lista, Celrà, ES;
Ma del Carmen Onrubia Miguel, Barcelona, ES;
Assignee:
Medichem, S.A., Barcelona, ES;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/38 ;
U.S. Cl.
CPC ...
C07F 9/38 ;
Abstract
The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.