The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2003
Filed:
Apr. 16, 1999
Applicant:
Inventors:
Paul A. Grieco, Gosport, IN (US);
D. James Morre, West Lafayette, IN (US);
Thomas H. Corbett, Gross Pointe Park, MI (US);
Frederick A. Valeriote, Utica, MI (US);
Assignee:
Advanced Research and Technology Institute, Inc., Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/135 ; A61K 3/134 ;
U.S. Cl.
CPC ...
A61K 3/135 ; A61K 3/134 ;
Abstract
The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.