The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2003
Filed:
Nov. 09, 2000
Applicant:
Inventors:
Minmin Qin, Pleasanton, CA (US);
Wai-Pan Chan, Castro Valley, CA (US);
Lin Chen, San Francisco, CA (US);
Paul A. Fitzpatrick, Albany, CA (US);
John M. Hendstrand, Davis, CA (US);
Dan J. Wendt, Walnut Creek, CA (US);
Gary N. Zecherle, Novato, CA (US);
Christopher M. Starr, Sonoma, CA (US);
Emil D. Kakkis, Novato, CA (US);
Assignee:
BioMarin Pharmaceutical Inc., Novato, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/00 ; C12N 9/00 ; C12N 9/24 ; C07K 1/00 ; C07K 1/400 ; C07K 1/700 ; A23J 1/00 ;
U.S. Cl.
CPC ...
C12Q 1/00 ; C12N 9/00 ; C12N 9/24 ; C07K 1/00 ; C07K 1/400 ; C07K 1/700 ; A23J 1/00 ;
Abstract
The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme as well as methods to treat certain genetic disorders including &agr;-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).