The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6569456 B1

PDF
Full Text
Expired
Date of Patent:
May. 27, 2003

Filed:

Jan. 05, 2001
Applicant:
Inventors:

Joaquina Faour, Buenos Aires, AR;

Juan A. Vergez, Buenos Aires, AR;

Assignee:

Osmotica Corp., Tortola, VG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/22 ; A61K 9/30 ; A61K 9/36 ;
U.S. Cl.
CPC ...
A61K 9/22 ; A61K 9/30 ; A61K 9/36 ;
Abstract

The present invention provides an osmotic device containing controlled release diltiazem in the core in combination with a rapid release ACE inhibitor, or diuretic, in an external coat. The delivery device of the invention can also be a chronotherapeutic osmotic device that provides a delayed and controlled release of diltiazem and a delay and rapid release of an ACE inhibitor or diuretic. A wide range of ACE inhibitors or diuretics can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One specific embodiment of the osmotic device includes an external coat that has been spray coated rather than compression coated onto the device. The device with spray coated external core is smaller and easier to swallow than the similar device having a compression coated external coat. The device is useful for the treatment of blood pressure or hypertension related disorders.


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