The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2003
Filed:
Jul. 10, 2002
Applicant:
Inventors:
Adriaan Antonius Wilhelmus Maria van Loon, Sambeek, NL;
Egbert Mundt, Millienhagen, DE;
Assignee:
Akzo Nobel N.V., Arnhem, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 6/300 ; A61K 3/912 ;
U.S. Cl.
CPC ...
A01N 6/300 ; A61K 3/912 ;
Abstract
The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284 (Ala) to 253 (His) and 284 (Thr) allowed bursa adapted Classical and Variant-E IBDV to grow in CEF cell culture. For GLS IBDV only a change of the codon for amino acid residue 284 was necessary.