Aminobenzophenones as inhibitors of il-1&bgr; and tnf-&agr;

Abstract

The present invention relates to a compound of general formula (I) wherein R , R , and R represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C -C )alkyl, (C -C )olefinic group, (C -C )alkoxy, (C -C )akylthio, (C -C )alkylamino, (C -C )alkoxycarbonyl, cyano, —CONH , phenyl, or nitro; further R can be hydrogen, and R can be carboxy and carbamoyl; R represents hydrogen, (C -C )alkyl, or allyl; X represents oxygen or sulphur; Q represents —(CO)—, —(CS)—, or a bond; Y represents (C -C )alkyl; (C -C )olefinic group; (C -C )monocyclic hydrocarbon group; or phenyl; any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R defined below; (C -C )alkyl substituted by one or more substituents selected for the group R ; or a group of the formula —(Z—O) —Z, wherein Z is a (C -C )alkyl, n is an integer >1; and no continuous linear sequence of atoms in the group Y exceeds 15; R represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C -C )alkoxy, (C -C )alkylthio, (C -C )alkylamino, (C -C )alkoxycarbonyl, cyano, azido, nitro, —COOH, —CONH , —CONHR′, or COONR′R′ wherein R′ represents (C -C )alkyl; or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.