The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2003
Filed:
Aug. 18, 1998
Alfred Jonczyk, Darmstadt, DE;
Simon Lawrence Goodman, Darmstadt, DE;
Beate Diefenbach, Darmstadt, DE;
Arne Sutter, Darmstadt, DE;
Horst Kessler, Garching, DE;
Merck Patent Gesellschaft, Darmstadt, DE;
Abstract
The invention relates to compounds of the formula (I) R —Q —X—Q —R , in which: Q , Q , each independent of one another, are missing or are —NH—(CH ) —CO—; R , R , each independent of one another, are missing or are cyclo-(Arg-Gly-Asp-Z), wherein Z is missing in side chain of Q or Q of if Q and/or Q missing, is bound to X, at least one of the groups R or R always having to be included; X is —CO—R —CO—, and if R —Q — or R —Q — are missing is R , R , Het-CO or a flourescent pigment residue linked through a —CONH—, —COO—, NH—C(═S)—N—, —NH—C(═O)—NH—, —SO NH—or —NHCO— bond; and Z, R , R , R , R , Het and n have the meaning given in claim 1. The invention also relates to the salts of said compounds. These compounds and their salts can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, angiogenic diseases and in tumor therapy.