Cyclic amine compounds as ccr5 antagonists

Abstract

A compound of formula (I) (wherein R is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R and R may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N —R .Y (R is a hydrocarbon group; Y is a counter anion); R is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G is a bond, CO or SO ; G is CO, SO , NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C aliphatic hydrocarbon which may be substituted; provided that J is methine when G is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).