The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2003
Filed:
Dec. 20, 2001
Applicant:
Inventors:
Christopher J. Baldwin, Santa Cruz, CA (US);
Conway C. Chang, San Francisco, CA (US);
Binh T. Dang, San Jose, CA (US);
Assignee:
Micrologix Biotech Inc., Vancouver, CA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/170 ; C07H 1/708 ;
U.S. Cl.
CPC ...
A61K 3/170 ; C07H 1/708 ;
Abstract
The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.