The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2003
Filed:
Mar. 02, 2001
Applicant:
Inventors:
Francesco Casu', Gallarate, IT;
Claudio Bernardi, Milan, IT;
Luciano Dho, Parabiago, IT;
Bruno Rosa, Motta Visconti, IT;
Assignee:
Pharmacia & Upjohn S.p.A., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
L12N 5/00 ;
U.S. Cl.
CPC ...
L12N 5/00 ;
Abstract
A surgical procedure (partial hepatectomy) in the nonhuman primate allows repeated removal of large liver tissue samples from a single animal for the preparation of liver tissue slices and primary cell culture of hepatocytes. The open biopsy procedure, alternating non-anatomic and anatomic partial liver resection monthly on the same liver lobe, follows a surgical protocol allowing animal welfare, survival, and multiple sampling (at least 8) from the same animal, thus reducing considerably the number of animals needed for research purposes.