The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2003
Filed:
Oct. 27, 2000
Applicant:
Inventors:
Xavier Paliard, San Francisco, CA (US);
Michael Houghton, Danville, CA (US);
Mark Selby, San Francisco, CA (US);
Assignee:
Chiron Corporation, Emeryville, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/929 ; A61K 3/912 ; A61K 3/812 ; C07K 1/400 ; C07K 1/408 ;
U.S. Cl.
CPC ...
A61K 3/929 ; A61K 3/912 ; A61K 3/812 ; C07K 1/400 ; C07K 1/408 ;
Abstract
The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4 and CD8 T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.