The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2003
Filed:
Dec. 08, 1999
Applicant:
Inventors:
Joerg Seebach, Boston, MA (US);
David H. Sachs, Newton, MA (US);
Harout DerSimonian, Wellesley, MA (US);
Christian LeGuern, Newton, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/800 ; C12N 5/02 ; C12N 1/500 ; A01K 6/7033 ;
U.S. Cl.
CPC ...
A61K 4/800 ; C12N 5/02 ; C12N 1/500 ; A01K 6/7033 ;
Abstract
Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic stem cell which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack.