The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2003
Filed:
Mar. 08, 2001
Applicant:
Inventors:
David Wallach, Rehovot, IL;
Jacek Bigda, Gdansk, PL;
Igor Beletsky, Pushino, RU;
Igor Mett, Rehovot, IL;
Hartmut Engelmann, Munich, DE;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/9395 ; C07K 1/628 ;
U.S. Cl.
CPC ...
A61K 3/9395 ; C07K 1/628 ;
Abstract
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.