The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 22, 2003

Filed:

Nov. 09, 1995
Applicant:
Inventors:

Steven James Burton, Peterborough, GB;

James C. Pearson, Cambridge, GB;

Peter A. D. Edwardson, Chester, GB;

Alan Menzies, Connah's Quay, GB;

Assignee:

E. R. Squibb & Sons, Inc., Princeton, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 5/00 ; C07K 1/700 ; C12N 1/102 ; G01N 3/353 ;
U.S. Cl.
CPC ...
A61K 5/00 ; C07K 1/700 ; C12N 1/102 ; G01N 3/353 ;
Abstract

Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized, powder cake. They have applicability in any case where avidin/biotin technology is used and are particularly important as compositions containing a thrombin-like enzyme, e.g., for preparation of a fibrin monomer and fibrin monomer-based fibrin sealants.


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