The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2003
Filed:
Nov. 03, 2000
Applicant:
Inventors:
Masafumi Matsuo, Suma-ku, Kobe, Hyogo 654-0151, JP;
Koji Ikeda, Kobe, JP;
Noriaki Emoto, Ashiya, JP;
Sunu Budhi Raharjo, Kobe, JP;
Yudha Nurhantari, Kobe, JP;
Kayoko Saiki, Takarazuka, JP;
Mitsuhiro Yokoyama, Kobe, JP;
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/64 ; C12N 1/557 ; C12N 1/563 ; C12N 1/579 ;
U.S. Cl.
CPC ...
C12N 9/64 ; C12N 1/557 ; C12N 1/563 ; C12N 1/579 ;
Abstract
Disclosed are metalloprotease proteins or their salts usable for treatment or prophylaxis of conformational diseases and for providing a screening kit for selection of carcinostatics and anti-metastatic agents. The metalloprotease proteins have an amino acid sequence set forth under SEQ ID NO:1 or NO:2 in the Sequence Listing. The proteins have a neutral optimal pH, hydrolyze endothelin 1, atrial natriuretic peptide and angiotensin I and are inhibited by 1,10-phenanthroline, phosphoramidon and thiorphan.