The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2003
Filed:
Mar. 13, 2001
Arthur J. L. Cooper, Croton on Hudson, NY (US);
John P. Blass, Bronxville, NY (US);
Cornell Research Foundation, Inc., Ithaca, NY (US);
Abstract
A method of diagnosing a (CAG) /Q -expansion disorder in an individual, said method including: obtaining a sample from an individual; combining the sample with o-phthaldialdehyde under conditions effective to form a test solution comprising an o-phthaldialdehyde derivative of N -(L-&ggr;-glutamyl)-L-lysine; and determining whether the test solution contains a concentration of the o-phthaldialdehyde derivative of N -(L-&ggr;-glutamyl)-L-lysine which is elevated in comparison to a normal concentration of the o-phthaldialdehyde derivative of N -(L-&ggr;-glutamyl)-L-lysine, wherein an elevated concentration in the test solution indicates that the individual has a (CAG) /Q -expansion disorder. Also disclosed are methods of measuring progression of a (CAG) /Q -expansion disorder and measuring therapeutic efficacy of a treatment for a (CAG) /Q -expansion disorder.