The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2003
Filed:
Apr. 17, 2002
Gergely Héja, Szentendre, HU;
Éva Csikós, Budapest, HU;
Csaba Gönczi, Budapest, HU;
Judit Halász, Budapest, HU;
Félix Hajdú, Budapest, HU;
István Hermecz, Budapest, HU;
László Kis, Budapest, HU;
Lajos Nagy, Szentendre, HU;
Andrea Sántáné Csutor, Budapest, HU;
Kálmán Simon, Budapest, HU;
Tiborné Szomor, Budapest, HU;
Györgyné Szvoboda, Dunakeszi, HU;
Sanofi-Synthelabo, Paris, FR;
Abstract
The invention relates to a process for the preparation of spiro[cis-4-(&bgr;-hydroxyethyloxy)cyclohexane-[3H]indol]-2′[1′H]-one derivatives of the formula (I) wherein R and R are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4′-cyclohexane-1′3′-[3H]indol]-2″[1″H]-one derivative of general formula (II), wherein R and R are as defined herein, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.