The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2003
Filed:
Jul. 17, 2001
Applicant:
Inventors:
Johannes Aebi, Basel, CH;
Denise Blum, Basel, CH;
Daniel Bur, Therwil, CH;
Alexander Chucholowski, San Diego, CA (US);
Henrietta Dehmlow, Grenzach-Wyhlen, DE;
Eric Argirios Kitas, Arlesheim, CH;
Bernd Michael Loeffler, Oberrimsingen, DE;
Ulrike Obst, Grenzach-Wyhlen, DE;
Sabine Wallbaum, Ostfildern, DE;
Assignee:
Hoffman-La Roche Inc., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/1454 ; A61K 3/140 ; A61K 3/14025 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/1454 ; A61K 3/140 ; A61K 3/14025 ; C07D / ; C07D / ;
Abstract
The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.