The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2003
Filed:
Nov. 02, 1999
Applicant:
Inventors:
Lyn M. Wise, Dunedin, NZ;
Andrew A. Mercer, Dunedin, NZ;
Loreen J. Savory, Dunedin, NZ;
Stephen B. Fleming, Dunedin, NZ;
Steven A. Stacker, Parkville, AU;
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/900 ; A61K 3/800 ; C07K 1/700 ;
U.S. Cl.
CPC ...
A61K 3/900 ; A61K 3/800 ; C07K 1/700 ;
Abstract
The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.