The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2003
Filed:
Jun. 21, 1999
Bcr-abl directed compositions and uses for inhibiting philadelphia chromesome stimulated cell growth
Applicant:
Inventors:
Ralph B. Arlinghaus, Bellaire, TX (US);
Jiaxin Liu, Bellaire, TX (US);
Gabriel Lopez-Berestein, Bellaire, TX (US);
Dai Lu, Pearland, TX (US);
Yun Wu, Houston, TX (US);
Assignee:
Board of Regents, The University of Texas Systems, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; C12N 1/563 ;
U.S. Cl.
CPC ...
C07H 2/104 ; C12N 1/563 ;
Abstract
The present invention provides methods for detecting and quantitating BCR-ABL gene products and other abnormal ABL gene products of Ph -positive leukemic cells. The invention further provides methods for determining the relative number of leukemic cells compared with normal ABL cells to assess the tumor burden of a patient. In another aspect, the methods of the present invention can be used to determine a specific phase of leukemia, particularly chronic-phase CML.