The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2003
Filed:
May. 08, 2002
Alexander Mark Gibson, Amersham, GB;
Marivi Mendizabal, Amersham, GB;
Richard Pither, Amersham, GB;
Shirley Elizabeth Pullan, Amersham, GB;
Vaughan Griffiths, London, GB;
Philip Duncanson, London, GB;
Amersham plc, Amersham, GB;
Abstract
The present invention relates to P or P-labelled bisphosphonates as radiotherapeutic radiopharmaceuticals. The P- or P-labelled bisphosphonates, which are chemically identical to the unlabelled agent, are expected to target the lesion site in an identical manner, but also deliver a significant radiocytotoxic effect to the surrounding cells. This should result, given the favorable energetics of the &bgr; particle emission from the P nuclide, in a loss of proliferative capacity of cells associated with the tumor lesion. The relative stability and in vivo localisation of bisphosphonates makes them good candidates as P/ P delivery vehicles.