The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2003

Filed:

Sep. 05, 2000
Applicant:
Inventors:

Debra Moore-Smith, Chesapeake, VA (US);

Robert K. O'Leary, Deltaville, VA (US);

Anne Wilson, Virginia Beach, VA (US);

Assignee:

LifeNet, Virginia Beach, VA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/532 ; C12N 5/00 ; A01N 1/00 ; C12M 1/34 ; C12M 1/36 ;
U.S. Cl.
CPC ...
A61K 3/532 ; C12N 5/00 ; A01N 1/00 ; C12M 1/34 ; C12M 1/36 ;
Abstract

The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid high volume, pulsatile acidification wave process. The process includes subjecting bone to two or more rapid pulse/drain cycles where one or more demineralizing acids are rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel, the vessel containing the bone is then rapidly refilled with the one or more demineralizing acids (pulsed). The process allows bone to be rapidly demineralized to a precise ans specific desired residual calcium level, without sacrificing osteoinductivity.


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