The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2003
Filed:
Nov. 02, 1999
Applicant:
Inventors:
Assignee:
D. Gen Limited, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/900 ; A61K 3/900 ; A61K 4/500 ; C12N 5/00 ;
U.S. Cl.
CPC ...
A61K 4/900 ; A61K 3/900 ; A61K 4/500 ; C12N 5/00 ;
Abstract
The present invention relates to a method of making a &bgr;-form of a prion protein which preferably has more &bgr;-sheet than &agr;-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the &bgr;-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native &agr;-form of a prion protein to a &bgr;-form, and to uses of identified compounds in medicine.