The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2003
Filed:
Dec. 22, 1999
Applicant:
Inventors:
Laura M. Bohn, Durham, NC (US);
Fang-Tsyr Lin, Durham, NC (US);
Marc G. Caron, Hillsborough, NC (US);
Robert J. Lefkowitz, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/400 ; C07K 1/700 ; C12Q 1/00 ; G01N 3/353 ; G01N 3/3567 ;
U.S. Cl.
CPC ...
C07K 1/400 ; C07K 1/700 ; C12Q 1/00 ; G01N 3/353 ; G01N 3/3567 ;
Abstract
The present invention provides a &bgr;arrestin knockout mouse useful for screeening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of &bgr;arrestin to phosphorylated &mgr; opioid receptors, and methods of screening a compound for activity in potentiating &mgr; opioid receptor agonist activity (e.g., morphine activity) by determining whether or not said compound inhibits &bgr;arrestin binding to a phosphorylated &mgr; opioid receptor.