The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2003
Filed:
Feb. 23, 2001
Applicant:
Inventors:
Mark P. Chadwick, Cambridge, GB;
Stephen J. Russell, Rochester, MN (US);
Assignee:
BioFocus Discovery Limited, Cambridge, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/70 ; C12Q 1/06 ; G01N 3/353 ; C12N 5/00 ; C12N 5/06 ;
U.S. Cl.
CPC ...
C12Q 1/70 ; C12Q 1/06 ; G01N 3/353 ; C12N 5/00 ; C12N 5/06 ;
Abstract
Methods are disclosed whereby inhibition of proteolytic activity causes an increase in delivery of a transferable label from a viral display package to a target cell. Assaying for the transferable label in the target cell in the presence of a test substance can identify the test substance as a protease inhibitor. Protease inhibitors so identified are used therapeutically, to treat conditions such as cancer, inflammation, rheumatoid arthritis and other autoimmune diseases, and infections, including AIDS, herpes, and hepatitis.