The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2003
Filed:
Nov. 02, 1999
Applicant:
Inventors:
George Y. Wu, Avon, CT (US);
Catherine H Wu, Avon, CT (US);
Assignee:
The University of Connecticut, Farmington, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 6/700 ; A01K 6/7033 ; A01K 6/7027 ;
U.S. Cl.
CPC ...
A01K 6/700 ; A01K 6/7033 ; A01K 6/7027 ;
Abstract
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at least in part, on the discovery that rats, tolerized in utero against human hepatocytes, were found to serve as long-term hosts for human hepatocytes introduced post-natally, and the introduced hepatocytes maintained their differentiated phenotype, as evidenced by continued production of human albumin.