The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2003
Filed:
Jun. 21, 2000
Applicant:
Inventors:
Dallas E. Hughes, Westboro, MA (US);
James L. Waters, Framingham, MA (US);
Yuriy M. Dunayevskiy, Natick, MA (US);
Assignee:
Cetek Corporation, Marlborough, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 2/726 ; G01N 2/7447 ; G01N 3/353 ; G01N 3/3543 ; G01N 3/3561 ;
U.S. Cl.
CPC ...
G01N 2/726 ; G01N 2/7447 ; G01N 3/353 ; G01N 3/3543 ; G01N 3/3561 ;
Abstract
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one to rank various ligands based on their relative affinity, i.e., the relative stability of the target/ligand complex during capillary electrophoresis under selected conditions. The method also enables selective detection of strong-to-moderate binding hit compounds, even in the presence of high concentrations of weaker, competitive hit compounds.