The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2003
Filed:
Apr. 06, 2001
Applicant:
Inventors:
Yves Langelier, Montreal, CA;
Bernard Massie, Montreal, CA;
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/500 ; C12N 7/01 ; C12N 9/00 ; C07K 1/700 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/500 ; C12N 7/01 ; C12N 9/00 ; C07K 1/700 ; C07H 2/104 ;
Abstract
An anti-apoptotic agent and a composition derived therefrom, and methods to prevent apoptosis in vivo and in vitro are provided. The anti-apoptotic agent comprises R1 subunit of Herpes simplex virus (HSV) ribonucleotide reductase, or its N-terminal portion of about 350 amino acids. HSV-R1 inhibited TNF-&agr; induced apoptosis, and blocked caspase 8 activation induced by TNF-&agr; and Fas-L expression.