The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2003
Filed:
Apr. 05, 2000
Applicant:
Inventors:
Paul Reichert, Montville, NJ (US);
Winifred W. Prosise, Ramsey, NJ (US);
Shahriar Shane Taremi, Upper Montclair, NJ (US);
Nanhua Yao, Edison, NJ (US);
Patricia C. Weber, Yardley, PA (US);
Assignee:
Schering Corporation, Kenilworth, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/929 ;
U.S. Cl.
CPC ...
A61K 3/929 ;
Abstract
The invention relates to the purification and crystallization of hepatitis C virus (HCV) NS3/NS4A polypeptide complex. Also, crystallization conditions for NS3/NS4A are provided. Further, the atomic coordinates for the NS3/NS4A protein are disclosed. Examples of its use for the determination of the three-dimensional atomic structures of HCV NS3/NS4A with substrate(s) or substrate analog(s) or inhibitor complexes are also provided.