The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2003
Filed:
Dec. 14, 2000
Applicant:
Inventors:
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/462 ; C12N 1/517 ; C12N 1/15 ; C12N 1/21 ;
U.S. Cl.
CPC ...
C07K 1/462 ; C12N 1/517 ; C12N 1/15 ; C12N 1/21 ;
Abstract
Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.