The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2003
Filed:
Jun. 26, 1998
Applicant:
Inventors:
Els A. J. M. Goulmy, Oegstgeest, NL;
Donald F. Hunt, Charlottesville, VA (US);
Victor H. Engelhard, Charlottesville, VA (US);
Assignee:
Rijksuniversiteit te Leiden, Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/800 ;
U.S. Cl.
CPC ...
A61K 3/800 ;
Abstract
The present invention relates to a peptide which is immunologically recognizable as a T cell epitope of the minor histocompatibility antigen H-Y. The peptide comprises amino acid sequence SPSVDKARAEL (SEQ ID NO:1), or FIDSYICQV (SEQ ID NO:2). The peptide is obtainable from the minor histocompatibility antigen H-Y. Providing a toxic moiety to the peptide eliminates T Cells having specific binding affinity for the peptide. The peptide induces tolerance for transplantations when administered to H-Y-negative recipients.