The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2003
Filed:
Mar. 27, 2001
Roya Mansour Sadeghi Guilani, Slough, GB;
Stephen Keith Wrigley, Slough, GB;
Sangeeta Bahl, Slough, GB;
Steven Michael Martin, Slough, GB;
David Andrew Kau, Slough, GB;
Jenny Seugkin Tang, Slough, GB;
Michael Moore, Slough, GB;
David James Hardick, Slough, GB;
Xenova Limited, , GB;
Abstract
A compound of formula (I), wherein &agr;X is ═O, ═N—OR , &bgr;NHR or &bgr;OH wherein R is H or C -C alkyl, bond a is oriented &ggr; or &dgr; and R is H, C -C alkyl which is unsubstituted or substituted by C -C aryl, or C -C cycloalkyl; &egr; is a bond when &zgr; and &eegr; are not bonds or, when X is ═O, &zgr; and &eegr; are both bonds and &egr; is not a bond; R and R , which are the same or different, are H or a halogen; R and R , which are the same or different, are H, C -C alkyl, C -C cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented &ggr; or &dgr;; and R is C -C alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase. A process for producing some of the compounds from a fungal strain, processes for producing synthetic analogues from these compounds and the use of the compounds in treating immunoinflammatory and cancerous conditions are also described.