The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2003
Filed:
Mar. 06, 2001
Applicant:
Inventors:
William Alexander Denny, Auckland, NZ;
Graham John Atwell, Auckland, NZ;
Brian Desmond Palmer, Auckland, NZ;
William Robert Wilson, Auckland, NZ;
Assignee:
Auckland Uniservices Limited, Auckland, NZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/944 ; A61K 3/1415 ; A61K 3/1395 ; A61K 3/1535 ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/944 ; A61K 3/1415 ; A61K 3/1395 ; A61K 3/1535 ; C07D / ; C07D / ; C07D / ;
Abstract
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl)-N-[2-(4-morpholino)ethyl]-2,4-dinitrobenzamide of Formula (A) was found to be highly active against all NR+ cell lines tested.