The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2003
Filed:
Jul. 28, 1999
Andrew Roy Buchman, Berkeley, CA (US);
Christian Burks, Berkeley, CA (US);
Helen Louise Francis-Lang, San Francisco, CA (US);
Lucile A. Gillett, San Mateo, CA (US);
Jonathan Cagampang Heller, San Francisco, CA (US);
Casey Casimir Kopczynski, Belmont, CA (US);
Jonathan Scott Margolis, San Carlos, CA (US);
Darren Mark Platt, San Francisco, CA (US);
Bindu Priya Reddy, Foster City, CA (US);
Candace Swimmer, San Francisco, CA (US);
John W. Winslow, El Granada, CA (US);
Yuling Luo, Castro Valley, CA (US);
Exelixis, Inc., S. San Francisco, CA (US);
Abstract
Tandem pore domain weak inward rectifying K (TWIK) channel nucleic acids and proteins that have been isolated from and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.