The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2003

Filed:

Aug. 28, 1998
Applicant:
Inventors:

Gary Ashley, Alameda, CA (US);

Melanie C. Betlach, Burlingame, CA (US);

Mary Betlach, San Francisco, CA (US);

Robert McDaniel, Palo Alto, CA (US);

Li Tang, Foster City, CA (US);

Assignee:

Kosan Biosciences, Inc., Burlingame, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/00 ; C12N 1/20 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 9/00 ; C12N 1/20 ; C07H 2/104 ;
Abstract

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.


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