The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2003
Filed:
Jul. 29, 1999
Gunars E. Valkirs, Escondido, CA (US);
Biosite Diagnostics, San Diego, CA (US);
Abstract
This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of in a biological sample. One embodiment provides methods for detection that involve assaying for both glutamate dehydrogenase and toxin A or toxin B. In another embodiment, the invention provides a highly sensitive assay for toxin A that is useful for determining whether a strain is toxigenic. This embodiment involves binding of toxin A to a moiety that reversibly binds to a capture moiety present on a magnetic bead. A magnetic field is applied to the sample to concentrate the toxin A, after which the magnetic beads are dissociated and removed from the solution to obtain a highly concentrated preparation of toxin A, thus making possible a very sensitive assay.