The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2002
Filed:
Jul. 16, 1997
Applicant:
Inventors:
Saroj K. Roy, Acton, MA (US);
Jin-Yan Tang, Shrewsbury, MA (US);
Assignee:
Avecia Biotechnology, Inc., Milford, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 2/100 ;
U.S. Cl.
CPC ...
C07H 2/100 ;
Abstract
The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleotide linkages of oligonucleotides. The invention provides a process to synthesize new sulfur transfer reagents and a process for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage and in solution, and highly efficient in sulfurization.