The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2002
Filed:
May. 11, 2001
Fumio Nakamura, Tokyo, JP;
Masahiko Hara, Wako, JP;
Riken, Wako, JP;
Abstract
A substrate for detecting base sequences that comprises a transparent support, a thin metal film formed on one side of the transparent support, and a self-assembled monolayer with a nonionic aromatic compound being an intercalator of nucleic acid polymers dispersed over the surface formed on the metal film. The substrate is manufactured, for example, by immersing a transparent support with a thin gold film formed on one side in a solution that contains a disulfide (S—S) compound containing anthracene for the intercalator of nucleic acid polymers form on the metal film. A nucleic acid polymer (probe or target) is immobilized to the monolayer of the substrate, another nucleic acid polymer (target or probe) is hybridized to the nucleic acid polymer immobilized to the monolayer, and the results of the hybridization can be detected by the Surface Plasmon Resonance method after washing.