The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2002
Filed:
Nov. 02, 2000
Anuschirwan Peyman, Kelkheim, DE;
Jochen Knolle, San Francisco, CA (US);
Gerhard Breipohl, Frankfurt, DE;
Karl-Heinz Scheunemann, Liederbach, DE;
Denis Carniato, Marcoussis, FR;
Jean-Francois Gourvest, Claye Souilly, FR;
Thomas Gadek, Oakland, CA (US);
Robert McDowell, San Francisco, CA (US);
Sarah Catherine Bodary, San Bruno, CA (US);
Robert Andrew Cuthbertson, North Fitzroy, AU;
Napoleane Ferrara, San Francisco, CA (US);
Other;
Abstract
The present invention relates to acylguanidine derivatives of formula (I) in which R , R , R , R , R , A, m and n have the meanings indicated in the patent claims, their physiologically tolerable salts and their prodrugs. The compounds of formula (I) are valuable pharmaceutical active ingredients. They are vitronectin receptor antagonists and inhibitors of bone resorption by osteoclasts and are suitable, for example, for the therapy or prophylaxis of diseases which are caused at least partially by an undesired extend of bone resorption, for example of osteoporosis. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use, in particular as pharmaceutical active ingredients, and pharmaceutical preparations comprising them.