The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2002
Filed:
Dec. 17, 1996
Applicant:
Inventors:
Leslie Berry, Burlington, CA;
Maureen Andrew, Oakville, CA;
Assignee:
Hamilton Civic Hospitals Research Development, Inc., Hamilton, CA;
Primary Examiner:
Int. Cl.
CPC ...
A61L 2/700 ; C07K 1/4435 ; A61K 3/816 ; A61K 6/00 ;
U.S. Cl.
CPC ...
A61L 2/700 ; C07K 1/4435 ; A61K 3/816 ; A61K 6/00 ;
Abstract
Novel conjugates of glycosaminoglycans, particularly heparin and dermatan sulfate, and amine containing species and therapeutic uses thereof are described. In particular, mild methods of conjugating heparins to proteins, such as antithrombin III and heparin cofactor II, which provide covalent conjugates which retain maximal biological activity are described. Uses of these conjugates to prevent thrombogenesis, in particular in lung airways, such as found in infant and adult respiratory distress syndrome, and on surfaces in contact with blood are also described.