The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2002
Filed:
Jan. 07, 2000
Applicant:
Inventors:
Ian Hector Frazer, St. Lucia, AU;
Jian Zhou, late of Jindalee, AU;
Assignee:
The University of Queensland, St. Lucia, AU;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/564 ; C12N 1/566 ; C12N 1/563 ; C12N 1/585 ; C12N 1/587 ;
U.S. Cl.
CPC ...
C12N 1/564 ; C12N 1/566 ; C12N 1/563 ; C12N 1/585 ; C12N 1/587 ;
Abstract
A synthetic polynucleotide and a method are disclosed for selectively expressing a protein in a target cell or tissue of a mammal. Selective expression is effected by replacing at least one existing codon of a parent polynucleotide encoding a protein of interest with a synonymous codon to produce a synthetic polynucleotide having altered translational kinetics compared to the parent polynucleotide. The synonymous codon is selected such that it has a higher translational efficiency in the target cell or tissue relative to one or more other cells or tissues of the mammal.