The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2002
Filed:
Apr. 28, 2000
Jerry L. Nadler, Charlottesville, VA (US);
David Bleich, Pasadena, CA (US);
Konkal-Matt R. Prasad, Charlottesville, VA (US);
City of Hope, Duarte, CA (US);
Abstract
This invention pertains to a method of protecting pancreatic &bgr;-cells from immune system-mediated cell damage through transduction of the cells with an adeno-associated viral vector encoding cytoprotective genes. These protected cells are suitable for transplantation into mammals and will be protected from rejection by the host. The method also may be used to protect pancreatic islet &bgr;-cells in situ for the primary prevention of immune-mediated destruction which leads to Type 1 diabetes. Pancreatic &bgr;-cells may be transduced with AAV vectors according to the invention for in vivo or ex vivo gene therapy.