The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2002
Filed:
Oct. 07, 1998
Applicant:
Inventors:
Achilles A. Demetriou, Bel Aire, CA (US);
Andreas Kamlot, Los Angeles, CA (US);
Jacek Rozga, West Lake Village, CA (US);
Assignee:
Cedars Sinai Medical Center, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/14 ; C12N 1/00 ; C12N 1/12 ; C12N 5/00 ; C12N 5/02 ;
U.S. Cl.
CPC ...
A61K 9/14 ; C12N 1/00 ; C12N 1/12 ; C12N 5/00 ; C12N 5/02 ;
Abstract
Disclosed is a universally-adaptable cell preconditioning and storage medium that can be used for the effective cryopreservation of cells at temperatures less than 4° C. The aqueous medium contains adenosine, a calcium channel blocker, and a nutrient-rich matrix that has a sufficient amount of cell metabolites to sustain the metabolic needs of the harvested cells while incubating the cells for a period of at least 10 minutes, without producing detectable levels of lactate or substantially depleting the metabolic substrates of the cell.