The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2002
Filed:
Jan. 11, 2000
Applicant:
Inventors:
Jon S. Morrow, Madison, CT (US);
Prasad Devarajan, New Haven, CT (US);
Zhushan Zhang, Hamden, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 2/106 ; C12P 2/102 ; C12N 9/02 ; C07K 1/00 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12P 2/106 ; C12P 2/102 ; C12N 9/02 ; C07K 1/00 ; C07H 2/104 ;
Abstract
The present invention provides a polypeptide of 26 amino acid residues that comprises the minimal ankyrin binding (MAB) domain. The MAB domain is responsible for the interactions between a Na,K-ATPase and ankyrin. The present invention also provides the three dimensional structure of the MAB domain. Also provided by the present invention are methods for modulating the interaction of a Na,K-ATPase and ankyrin.