The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2002
Filed:
Jul. 26, 2000
Theodore Russell Holman, Santa Cruz, CA (US);
Rakesh Mogul, Santa Cruz, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Allosteric inhibitors of lipoxygenase and methods for their use are provided. In many embodiments, the allosteric inhibitors are sulfated long chain alkenyl compounds. The compounds of these embodiments are long chain monounsatured alkenyl compounds having a single sulfate moiety at the 1 position. In many embodiments, the subject compounds range in length from about 14 to 22 carbon atoms and the site of unsaturation is located between the 8 and 14 positions. Specific compounds of interest include 9-oleyl sulfate; 9-palmitoleyl sulfate and 11-eicosenyl sulfate. The subject compounds exhibit lipoxygenase inhibitory activity. As such, the subject compounds find use in treating disease conditions characterized by the presence of undesirable lipoxygenase activity. Also provided are pharmaceutical preparations of the subject compounds.