The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2002
Filed:
Jun. 19, 2000
Applicant:
Inventors:
Michael J. Mastrangelo, Jenkintown, PA (US);
Edmund C. Lattime, Princeton, NJ (US);
David Berd, Wyncote, PA (US);
Laurence C. Eisenlohr, Merion, PA (US);
Assignee:
Thomas Jefferson University, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/800 ; A61K 3/100 ; C12N 5/02 ; C12N 1/574 ; C12N 1/563 ;
U.S. Cl.
CPC ...
A61K 4/800 ; A61K 3/100 ; C12N 5/02 ; C12N 1/574 ; C12N 1/563 ;
Abstract
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.