The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2002
Filed:
Oct. 26, 2001
Larry Kenneth Truesdale, San Diego, CA (US);
Richard A. Bychowski, Cardiff, CA (US);
Javier Gonzalez, Oceanside, CA (US);
Atsuo Kuki, Encinitas, CA (US);
Ranjan Jagath Rajapakse, San Diego, CA (US);
Min Teng, San Diego, CA (US);
Dan Kiel, San Diego, CA (US);
Daljit S. Dhanoa, West Chester, PA (US);
Yufeng Hong, San Diego, CA (US);
Tso-sheng Chou, San Diego, CA (US);
Anthony L. Ling, San Diego, CA (US);
Michael David Johnson, Cardiff, CA (US);
Vlad Edward Gregor, San Diego, CA (US);
Agouron Pharmaceuticals, Inc., La Jolla, CA (US);
Abstract
Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described.