The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2002
Filed:
Feb. 02, 2000
Bora E. Baysal, Pittsburgh, PA (US);
Robert E. Ferrell, Pittsburgh, PA (US);
Bernie J. Devlin, Pittsburgh, PA (US);
Joan E. Willett-Brozick, Pittsburgh, PA (US);
University of Pittsburgh, Pittsburgh, PA (US);
Abstract
The present invention is directed to oxygen sensing. The present invention provides methods for correcting (or providing for) oxygen sensing in cells. Preferably, the methods involve supplying the SDHD gene or cybS protein, or any of the other components of the mitochondrial complex II cytochrome b oxygen sensing complex in an amount which restores oxygen sensing to affected cells, and thus facilitates normoxic conditions. More specifically, the present invention relates to mutations in the SDHD gene in human cancers and their use in the diagnosis and prognosis of mammalian cancer.